Complete Diabetes Medications Table

Updated December 17, 2019. To quickly search this medication table hold Ctrl+f (windows) or Cmd+f (mac) and type your search term; hit enter. 

Diabetes Medication Classes

For quick access, click the medication class:

 

Alpha-Glucosidase Inhibitor

Generic name
Brand names (*coverage) Cost/Month
 Available Strengths
(max daily dose)
Usual Dosing  Health Canada Indications
 Acarbose
Glucobay® (B) $24-$33
 50 or 100 mg Three times daily
(before meals)

Monotherapy or in combination with metformin, sulfonylurea or insulin



Biguanide (Metformin)

Generic name
Brand names (*coverage) Cost/Month
 Available Strengths
(max daily dose)
Usual Dosing  Health Canada Indications
 Metformin
Glucophage® (B) $4
 500 mg, 850 mg
‚Äč(max 2000-2500 mg/day) 
 
2-3 times daily 

Monotherapy or in combination with other antihyperglycemic agents

 Metformin extended release
Glumetza® (NB) $18-$74

500 mg, 1000 mg 
(max 2000 mg/day)
  Once daily   Monotherapy or in combination with other antihyperglycemic agents

 

DPP-4 Inhibitors

Generic name
Brand names (*coverage) Cost/Month
 Available Strengths
(max daily dose)
Usual Dosing  Health Canada Indications
Alogliptin
Nesina® (NB) $66
  6.25 mg, 12.5 mg, 25 mg
(max 25 mg/day)
 Once daily
  • Monotherapy or in combination with metformin, sulfonylurea, pioglitazone or insulin.
  • Use of DPP-4 inhibitors with SGLT-2 inhibitors may not be outlined in the product monograph(s), but is an acceptable combination according to research.
Linagliptin
Trajenta® (SA) $79
5 mg
(max 5 mg/day)
Once daily

  • Monotherapy or in combination with metformin , sulfonylurea or with empagliflozin. 
  • Use of linagliptin with insulin may not be indicated in the product monograph, but is an acceptable combination according to research. 
  • Use of DPP-4 inhibitors with SGLT-2 inhibitors may not be outlined in the product monograph(s), but is an acceptable combination according to research.
  • Boehringer 6m compassionate supply form for MDs.
Saxagliptin
Onglyza® (SA) $75-$88 
 2.5 mg, 5 mg
(max 5 mg/day)
Once daily

  • In combination with metformin, sulfonylurea, dapagliflozin or insulin. 
  • Use of DPP-4 inhibitors with SGLT-2 inhibitors may not be outlined in the product monograph(s), but is an acceptable combination according to research.
 Sitagliptin
Januvia® (SA) $92 
25 mg, 50 mg, 100 mg
(max 100 mg/day)
Once daily 

  • Monotherapy or in combination with metformin, sulfonylurea, pioglitazone, dapagliflozin or insulin.
  • Use of DPP-4 inhibitors with SGLT-2 inhibitors may not be outlined in the product monograph(s), but is an acceptable combination according to research.
.

  

GLP-1 Agonists (Incretin Mimetics)

Generic name
Brand names (*coverage) Cost/Month
 Available Strengths
(max daily dose)
Usual Dosing  Health Canada Indications
 Dulaglutide
Trulicity® (NB) $203
0.75 mg, 1.5 mg
(max 1.5 mg/week)
Once weekly injection  Monotherapy or in combination with metformin, sulfonylurea or insulin. 
Exenatide ER (Extended Release)
Bydureon® (NB) $123
2 mg
(max 2 mg/week)
Once weekly injection Monotherapy or in combination with metformin, sulfonylurea or basal insulin. 
Exenatide ER (Extended Release)      Bydureon BCise® (NB); not yet marketed                      2 mg                    (max 2 mg/week) Once weekly injection  Combination with metformin or sulfonylurea. 
 Exenatide
Byetta® (NB) $144
 5 mcg, 10 mcg
(max 20 mcg/day)
Twice daily injection  Add-on to metformin or sulfonylurea or glargine.  
 Liraglutide
Victoza® (NB) $91- $272
0.6 mg, 1.2 mg, 1.8 mg
(max 1.8 mg/day)
 Once daily injection  Monotherapy or in combination with metformin, sulfonylurea or basal insulin. Use with prandial insulin at DCC does not require note to prescriber. 
Lixisenatide
Adlyxine® (NB) $113
10 ug, 20 ug
(max 20 ug/day)
Once daily injection Monotherapy or use with metformin, sulfonylurea, pioglitazone or basal insulin.
Semaglutide
Ozempic® (SA) $195 
(NIHB Coverage -Non-insured health benefits for First Nations and Inuit)

 0.25, 0.5 mg, 1 mg
(max 1 mg/week) 
Once weekly injection  Monotherapy or in combination with metformin, sulfonylurea or basal insulin. Use with prandial insulin at DCC does not require note to prescriber.

Secretagogues (Sulfonylureas and Meglitinides)

Generic name
Brand names (*coverage) Cost/Month
 Available Strengths
(max daily dose)
Usual Dosing  Health Canada Indications
 Gliclazide
Diamicron® (B) $3 - $11
80 mg
(max 320 mg/day)
 Twice daily

 "Non- ketosis prone, maturity onset or adult type" diabetes
Gliclazide modified release
Diamicron MR® (B) $3 - $14
30 mg, 60 mg  
(max 120 mg/day)
Once daily 

"Non- ketosis prone, maturity onset or adult type" diabetes 
Glimepiride
Amaryl® (NB) $29-67
1 mg, 2 mg, 4 mg 
(max 8 mg/day) 
Once daily 

Monotherapy or with metformin or insulin
Glyburide
Diabeta® (B) $2-$6
2.5 mg, 5 mg 
(max 20 mg/day) 
Twice daily
 
Type 2 Diabetes 
Repaglinide
Gluconorm® (B) $7
0.5 mg, 1 mg, 2 mg 
(max 4 mg/meal; 16 mg/day)
At meals
(optional HS snack) 

Monotherapy or with metformin or rosiglitazone 

 SGLT Inhibitors (SGLT-1 and SGLT-2 Inhibitors)

Generic name
Brand names (*coverage) Cost/Month
 Available Strengths
(max daily dose)
Usual Dosing  Health Canada Indications
 Canagliflozin (SGLT 2)
Invokana® (SA) $84
 100 mg, 300 mg
(max 300 mg/day)
Once daily 
  • Monotherapy or in combination with metformin, sulfonylurea, pioglitazone, sitagliptin or insulin or as add-on combination in patients with established cardiovascular disease.
  • Use of other DPP-4 inhibitors with SGLT-2 inhibitors may not be outlined in the product monograph(s), but is an acceptable combination according to research. 
Dapagliflozin (SGLT 2)
Forxiga® (SA) $82
5 mg, 10 mg
(max 10 mg/day)
Once daily 
  • Monotherapy or in combination with metformin, sulfonylurea, sitagliptin or insulin. 
  • Use of other DPP-4 inhibitors with SGLT-2 inhibitors may not be outlined in the product monograph(s), but is an acceptable combination according to research.
 Empagliflozin (SGLT 2)
Jardiance® (SA) $81
10 mg, 25 mg
(max 25 mg/day)
Once daily  
  • Monotherapy or in combination with metformin, sulfonylurea, pioglitazone, linagliptin or insulin or as add-on combination in patients with established cardiovascular disease.
  • Use of other DPP-4 inhibitors with SGLT-2 inhibitors may not be outlined in the product monograph(s), but is an acceptable combination according to research.
  • Boehringer 6m compassionate supply form for MDs.
Ertugliflozin (SGLT 2)
Steglatro® (NB) $74
5 mg, 15 mg
(max 15 mg/day)
Once daily (morning)
  • Monotherapy or in combination with metformin, sitagliptin.
  • Use of DPP-4 inhibitors with SGLT-2 inhibitors may not be outlined in the product monograph(s), but is an acceptable combination according to research.
Sotagliflozin (SGLT 1 & 2 Inhibitor)
Zynquista® 
Not yet approved by Health Canada
Not yet approved by Health Canada  
  •  Not yet approved by Health Canada
  •  Indications are expected to be with type 1 diabetes first. (Consideration for type 2 diabetes requires completion of cardiovascular outcome trials.)
  • Use of DPP-4 inhibitors with SGLT-2 inhibitors may not be outlined in the product monograph(s), but is an acceptable combination according to research.

Thiazolidinediones (TZDs)

Generic name
Brand names (*coverage) Cost/Month
 Available Strengths
(max daily dose)
Usual Dosing  Health Canada Indications
 Rosiglitazone
Avandia® (SA) $31 - $69
2 mg, 4 mg, 8 mg 
(max 8 mg/day)
Once daily

In combination with metformin or sulfonylurea. Prior to prescribing AVANDIA, physicians must: Document the eligibility of patients to meet the above criteria; Counsel each patient on the risks and benefits of AVANDIA, including the cardiovascular risks; and Obtain the patient’s written informed consent to take the drug. 
Pioglitazone
Actos® (SA) $10- $21
15 mg, 30 mg, 45 mg
(max 45 mg/day)
Once daily 

Monotherapy or in combination with metformin or sulfonylurea.

 

 Combination Medications

Generic name (class)
Brand names (*coverage) Cost/Month
 Available Strengths
(max daily dose)
Usual Dosing  Health Canada Indications
 Alogliptin (DPP-4) + Metformin
Kazano® (NB) $72
12.5 mg / 500 mg
12.5 mg / 850 mg
12.5 mg / 1000 mg
(max 25 mg + 2000 mg/day)
Twice daily Alone or in combination with pioglitazone or insulin 
Linagliptin (DPP-4) + Metformin
Jentadueto® (SA) $83
2.5 mg + 500 mg
2.5 mg + 850 mg
2.5 mg + 1000 mg
(max 5 mg + 2000 mg/day) 
Twice daily Alone or in combination with sulfonylurea or empagliflozin. 
Boehringer 6m compassionate supply form (MDs).
Sitagliptin (DPP-4) + Metformin
Janumet® (SA) $100
50 mg / 500 mg
50 mg / 850 mg
50 mg / 1000 mg 
(max 100 mg + 2000 mg/day)
Twice daily Alone or in combination with sulfonylurea, pioglitazone or insulin. 
Sitagliptin (DPP-4) + Metformin modified release
Janumet XR® (SA) $50 - $99
50 mg / 500 mg
50 mg / 1000 mg
100 mg / 1000 mg 
(max 100 mg + 2000 mg/day)

Once daily with a meal preferably in the evening 

Alone or in combination with sulfonylurea, pioglitazone or insulin. 
Sitagliptin (DPP-4) + Ertugliflozin (SGLT-2) Steglujan® (NB) No cost available             100 mg / 5 mg              100 mg / 15 mg  Once daily  Metformin 
Saxagliptin (DPP-4) + Metformin 
Komboglyze® (SA) $76
2.5 mg + 500 mg
2.5 mg + 850 mg
2.5 mg + 1000 mg
(max 5 mg + 2000 mg/day)  
 Twice daily  Alone or in combination with sulfonylurea or insulin.
Saxagliptin (DPP-4) + Dapagliflozin (SGLT-2) 
QTERN® (NB) $ - cost not available; not yet marketed
5 mg / 5 mg
5 mg / 10 mg 
(max 5 mg / 10 mg/day)
Once daily On metformin and saxagliptin alone or
 already controlled with metformin, saxagliptin and dapagliflozin. Can be used with insulin. 
Canagliflozin (SGLT-2) + Metformin
Invokamet® (NB) $95
50 mg / 500 mg
50 mg / 850 mg
50 mg / 1000 mg 
150 mg / 500 mg
150 mg / 850 mg
150 mg / 1000 mg 
(max 300 mg + 2000 mg/day)
Twice daily  Alone or in combination with sulfonylurea, pioglitazone or insulin.
Canagliflozin (SGLT-2) + Metformin modified release
Invokamet XR® (NB); not yet marketed 
50 mg / 500 mg
50 mg / 1000 mg 
150 mg / 500 mg
           150 mg / 1000 mg             (max 300 mg + 2000 mg/day)
Once daily  Alone or in combination with sulfonylurea, pioglitazone or insulin.
Dapagliflozin (SGLT-2) + Metformin
Xigduo® (SA) $74
5 mg / 850 mg
5 mg / 1000 mg
(max 10 mg + 2000 mg/day)
Twice daily  Alone or in combination with sulfonylurea, sitagliptin or insulin. 
Empagliflozin (SGLT-2) + Metformin
Synjardy® (NB) $83
5 mg / 500 mg
5 mg / 850 mg
5 mg / 1000 mg 
12.5 mg / 500 mg
12.5 mg / 850 mg
12.5 mg / 1000 mg
(max 25 mg + 2000 mg/day)
Twice daily 

 Alone or in combination with sulfonylurea, pioglitazone or insulin (not premix).

Boehringer 6m compassionate supply form (MDs).

Empagliflozin (SGLT-2) + Linagliptin (DPP-4)
Glyxambi® (NB) $142
10 mg / 5 mg
25 mg / 5 mg
(max 25 mg + 5 mg/day) 
Once daily  Metformin 
Ertugliflozin (SGLT-2) + Metformin Segluromet® (NB) $74    2.5 mg / 500 mg
2.5 mg / 1000 mg
7.5 mg / 500 mg
7.5 mg / 1000 mg
(max 15 mg / 2000 mg )          
Twice daily  Sitagliptin 
Insulin degludec + liraglutide (GLP-1)
Xultophy® (NB) $185-309

1 unit of Xultophy contains 1 unit of degludec and 0.04 mg liraglutide (fixed ratio)

Starting dose: 16 units
Maximum dose: 50 units

Once daily injection
  • Type 2 diabetes in combination with metformin, with or without sulfonylurea, when these combined with basal insulin (< 50 units daily) or liraglutide (less than or equal to 1.8 mg daily), do not provide adequate glycemic control.
 Insulin glargine + lixisenatide (GLP-1)
Soliqua®  (NB) $228 at max dose
1 unit of SOLIQUA contains 1 unit of insulin glargine and 0.33 mcg lixisenatide (fixed ratio)

Starting dose: 15 units/day or 30 units/day
Maximum dose:  60 units/day
 Once daily injection
  • Type 2 diabetes on basal insulin (< 60 units daily and > 15 units per day) alone or in combination with metformin
  • Taken before the first meal.
  • Starting Doses: 15 units Soliqua  (if current glargine dose < 30 units); 30 units Soliqua (if current glargine dose 30 to <60 units.)
  • Take oral contraceptives at least 1 hour before or at least 11 hours after the dose of SOLIQUA.
  • Suggested adjustments by fasting glucose of past 3 days:
    > 7.8 mmol/L add 4 units
    > 5.6 to < 7.8 mmol/L add 2 units
    4.4 to 5.6 mmol/L, no change
    < 4.4 mmol/L subtract 2 units

  

Insulins

For quick access, click the type of insulin. Or,  hold Ctrl+f (windows) or Cmd+f (mac) and type your search term; hit enter.

 

 Bolus Insulins

Pharmacodynamic action bolus insulins

Generic name
Brand names (*coverage) Cost/box
 Pharmacodynamics
Onset/Peak/Duration
Discard after room temp  Dosing Considerations
Aspart 
Novorapid® (B)
vial $30; cartridges $61;  prefills $64

Novorapid 

10-20 min / 1-3 hrs / 3-5 hrs

 28 days
  • May inject up to 10 minutes before a meal 
Faster Insulin Aspart
Fiasp® (coverage under review)
vial $30, cartridges $61, prefills $63 

Fiasp 

5-15 min / 1-3 hrs / 3-5 hrs

 28 days
  • May inject 2 mins before meal and up to 20 mins after starting meal
  • Should not be mixed with other insulins
  • Onset is 5 mins earlier than insulin aspart
  • Time to peak is 11mins faster than insulin aspart
  • Offset of effect occurs 12-14 mins earlier than insuilin aspart

Lispro 100 u/mL
Admelog® (NB) 
vial $NA; cartridges $NA; prefills $NA

30-45 min/ 1-3 hr / 3-5 hr  28 days  
Lispro 100 u/mL
Humalog® (B)
vial $29; cartridges $58; prefills $57

Humalog100or200u 

30-45 min / 1-3 hr / 3-5 hrs

28 days   
Lispro 200 u/mL
Humalog® (B)
prefills $107

Same as Lispro 100 u/mL 

30-45 min / 1-3 hr / 3-5 hrs

28 days
  • Reserved for patients using > 20 units per day of rapid insulin.
  • Not to be mixed with other insulins
  • Not to be administered via SC infusion pump (not tested)
Glulisine
Apidra® (B)
vial $28; cartridges $53;  prefills $53

Apidra 

10-15 min / 1-1.5 hrs / 3-5 hrs

 28 days
  • Must not be refrigerated once opened
Regular Insulin
Humulin R® (B)
vial $24; cartridges $47

Refer to "regular insulin" line in the image Pharmacodynamic Action Profiles of Bolus Insulins 

30-60 min / 2-4 hrs / 6-8 hrs 

28 days  
Regular Insulin
 Novolin ge Toronto® (B)
vial $24; cartridges $47

Refer to "regular insulin" line in the image Pharmacodynamic Action Profiles of Bolus Insulins 

30-60 min / 2-4 hrs / 6-8 hrs

One month  
Insulin, human biosynthetic
Entuzity® (NB) 500 u/mL - acts as bolus and basal. See in the Basal Insulin Chart below. 
See in basal chart below 28 days  

  Basal Insulins

Pharmacodynamics long acting insulins

Generic name
Brand names (*coverage) Cost/box

Pharmacodynamics
Onset/Peak/Duration
Discard after room temp  Dosing Considerations
Degludec
Tresiba® (B) 2 concentrations
 100 u/mL: prefills $111
200 u/mL: prefills $133
Also see Combination Medications

Tresiba

1 hr / no peak / 42 hrs

8 weeks 
  • Doses dialed are per one "normal" unit; e,g,  80 units u100 = 80 units u200; the latter is contained in less volume. 
  • U100 pen delivers doses in 1 unit increments up to 80 unit per dose
  • U200 pen delivers doses in 2 unit increments up to 160 unit increments
  • Missed doses may be taken when remembered (during waking hrs). Ensure at least 8 hrs between missed dose and the next dose.
  • Steady state serum concentration is reached after 3-4 days. You may wish to use the  Tresiba titration handout
  • Reduce by 20% if patient has type 1 diabetes or if switching from bid basal
  • Also available as the combination medication  Xultophy® (degludec + liraglutide). See combination medications section
 Detemir 
Levemir® (B)
 cartridges $108; prefills $111

  Levemir

1.5 hrs /  no peak / 16-24 hrs

42 days 
(6 weeks)


Insulin, human biosynthetic
(basal and/or bolus)
Entuzity® (NB) 500 u/mL
prefills 2/box $94
prefills 5/box $237
(each pen has 1500 units)

Entuzity15 15 min / 4-8  hrs / 17-24 hrs

28 days 

 

  • Indicated for those requiring over 200 units insulin/day
  • Onset similar to U-100
  • Peak slightly lower than Humulin R U100
  • Time to peak is delayed (vs. Humulin R)
  • Dose 30 minutes before meal
  • Given 2-3 times daily
  • When switching to Entuzity and HbA1c < 8% reduce TDD by 20%
  • Pen delivers 5 unit increments
Insulin, human biosynthetic
Humulin N ® (B)
vial $24; cartridges $47; prefills $47

Humulin N 

1-2 hrs / 5-8 hrs / 14-18 hrs

28 days   
Insulin, human biosynthetic
Novolin ge NPH® (B)
vial $24; cartridges $48

Refer to NPH line in the image Pharmacodynamic Action Profiles of Long-Acting Insulins 

1-2 hrs / 5-8 hrs / 14-18 hrs

 One month  
Glargine
Lantus® (B)
vial $62; cartridges $93; prefills $93
Also see Combination Medications for Soliqua®

Lantus 

1.5 hrs / no peak / 24 hrs

28 days 
  •  Reduce by 20% when switching from Toujeo to Lantus.
Glargine
Basaglar® (B)
cartridges $69; prefills $69

Basaglar 

1.5 hrs / no peak / 24 hrs

 28 days  
Glargine 300 u/mL
Toujeo® (NB)
1.5 mL (450 unit) prefilled pens $79  

Toujeo 

up to 6 hrs / no peak / up to 36 hrs

42 days
(6 weeks) 
  • The prescribed dose of TOUJEO should always be expressed in units of insulin.
  • See Toujeo dosing handout.
Glargine 300 u/mL 
Toujeo Doublestar
3 mL (900 unit) prefilled pens
Health Canada approved, not yet marketed

Toujeo

up to 6 hrs / no peak / up to 36 hrs

42 days
(6 weeks)
  • The prescribed dose of TOUJEO should always be expressed in units of insulin.
  • See Toujeo dosing handout.

 

  Mixed Insulins

Generic name
Brand names (*coverage) Cost/Month
Pharmacodynamics
Onset/Peak/Duration
Discard after room temp (days) Dosing Considerations
Lispro insulin (% Humalog)/ lispro protamine 
Humulin® Mix25 (B) 
Cartridges $59, Prefills $58

Humulin® Mix50 (B) 
Cartridges $58, Prefills $57

Per insulins lispro (Humalog) and N   28 days

30% regular insulin (R) / 70% insulin isophane (N), 
Humulin®  30/70 (B)
vial $24, cartridges $47
Per insulins R and N  28 days  

 Regular insulin (%Toronto) / insulin (%NPH)
Novolin® ge 30/70 (B)
vial $24, cartridges $46

Novolin® ge 40/60 (B)
cartridges $46

Novolin® ge 50/50 (B) 
cartridges $46

Per insulins Toronto and NPH   1 month  
30% soluble insulin aspart (rapid)/
 70% insulin aspart protamine crystals (NPH)
NovoMix® 30 (NB)
cartridges $56
Per insulins aspart (Novorapid) and NPH  1 month  

 

Glucagon

Generic name
Brand names (*coverage) Cost/Month
Storage Supporting materials and other considerations
glucagon nasal powder
BAQSIMI™
Over $132 (detailed cost pending)
Store BAQSIMI in the shrink wrapped tube at temperatures up to 30°C (86°F).  Lilly BAQSIMI (glucagon nasal powder) Patient Instructions
glucagon injection
Glugagon Lilly (B)
$89.97 per one kit
Prior to reconstitution, Vials of GLUCAGON and prefilled Hyporets of Diluting Solution may be stored at controlled room temperature, 15° to 30°C

 Lilly Glucagon (injected) Instructions Video

Lilly Glucagon (injected) Patient Print Instructions 

glucagon injection
GlucaGen® NovoNordisk (B)
$84.41 per one kit
Prior to reconstitution, the shelf life of the product is 3 years. GlucaGen® should be stored at a temperature not exceeding 2-8°C. The sealed container should be protected from light and freezing should be avoided.  NovoNordisk GlucaGen (injected) Patient Instructions
     

 

 

*Verify Alberta Blue Cross coverage through their database